Although analytical instrument has enjoyed unprecedented improvements in recent years, resulting in miniaturization, enhanced sensitivity, robust control systems as well as extended separation and detection capability, analytical and bioanalytical sample preparation still remain as the most challenging and time-consuming step in the analytical workflow. Collection of a representative sample is generally followed by a series of operations, collectively known as sample preparation and often includes filtration, centrifugation, protein precipitation, analyte extraction, elution in organic solvent, solvent evaporation, and sample reconstitution. Many of these steps are carried out manually that ultimately prolongs the overall analysis time. Capsule Phase Microextraction (CPME), a green and new generation sample preparation technique, has been developed to streamline current state-of-the-art of sample preparation practices. It exploits the advanced material properties of inorganic-organic hybrid sorbents, integrates the filtration and sample diffusion mechanism into the device, and provides the independence of sample preparation both in the laboratory and in the field without sacrificing the convenience of the analyst and the quality of the analytical data. The article describes the development of CPME and explains its advantageous features to the current and future analytical chemists and separation scientists.  

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Journal of Chromatography and Separation techniques is a peer-reviewed (refereed), academic, open-access, international scientific journal which provides a global scholarly platform to scientists, academicians and researchers to disseminate knowledge in the form of critical and informed articles related to separation science. If you are investigating on such novel and innovative areas of separation science then kindly consider contributing it to our upcoming issue Volume 12| Issue 1 (2021). Join hands with the Journal of Chromatography and Separation techniques in disseminating knowledge to the tertiary end users for the overall development in the field of separation science.

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